Antivirulence DsbA inhibitors attenuate Salmonella enterica serovar Typhimurium fitness without detectable resistance
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منابع مشابه
Triclosan resistance in Salmonella enterica serovar Typhimurium.
OBJECTIVES The aim of this study was to characterize the mechanisms of resistance to triclosan in Salmonella enterica serovar Typhimurium. METHODS Mutants resistant to triclosan were selected from nine S. enterica serovar Typhimurium strains. Mutants were characterized by genotyping, mutagenesis and complementation of fabI and analysis of efflux activity. Fitness of triclosan-resistant mutant...
متن کاملChanges in antimicrobial resistance in Salmonella enterica serovar typhimurium.
Emerging Infectious Diseases Vol. 6, No. 4, July–August 2000 436 3. Glynn MK, Bopp C, Dewitt W, Dabney P, Mokhtar M, Angulo FJ. Emergence of multidrug-resistant Salmonella enterica serotype typhimurium DT104 infections in the United States. N Engl J Med 1998;338:1333-8. 4. Smith KE, Besser JM, Hedberg CW, Leano FT, Bender JB, Wicklund JH, et al. Quinolone-resistant Campylobacter jejuni infectio...
متن کاملGenetic analysis of colistin resistance in Salmonella enterica serovar Typhimurium.
Colistin is a cyclic cationic peptide that kills gram-negative bacteria by interacting with and disrupting the outer membrane. We isolated 44 independent mutants in Salmonella enterica serovar Typhimurium with reduced susceptibility to colistin and identified 27 different missense mutations located in the pmrA and pmrB genes (encoding the regulator and sensor of a two-component regulatory syste...
متن کاملArginine-dependent acid resistance in Salmonella enterica serovar Typhimurium.
Salmonella enterica serovar Typhimurium does not survive a pH 2.5 acid challenge under conditions similar to those used for Escherichia coli. Here, we provide evidence that S. enterica serovar Typhimurium can display arginine-dependent acid resistance (AR) provided the cells are grown under anoxic conditions and not under the microaerobic conditions used for assessment of AR in E. coli. The rol...
متن کاملAntimicrobial Resistance of Salmonella enterica Serovar Typhimurium in Shanghai, China
We aimed to analyze the antimicrobial resistance phenotypes and to elucidate the molecular mechanisms underlying resistance to cephalosporins, ciprofloxacin, and azithromycin in Salmonella enterica serovar Typhimurium isolates identified from patients with diarrhea in Shanghai. The isolates showed high rates of resistance to traditional antimicrobials, and 20.6, 12.7, and 5.5% of them exhibited...
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ژورنال
عنوان ژورنال: FASEB BioAdvances
سال: 2021
ISSN: 2573-9832,2573-9832
DOI: 10.1096/fba.2020-00100